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KMID : 0894520070110020067
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Development & Reproduction
2007 Volume.11 No. 2 p.67 ~ p.77
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Directed Differentiation of Pancreatic Islets from Human Embryonic Stem Cells and Cell Therapy of Diabetes Mellitus
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Kim Suel-Kee
Shim Joong-Hyun
Woo Dong-Hun
Kim Jong-Hoon
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Abstract
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Replacement of insulin-producing cells represents an almost ideal treatment for patients with diabetes mellitus type 1. Transplantation of pancreatic islets of Langerhans is limited by the lack of donor organs. Therefore, generation of insulin-producing cells from human embryonic stem cells represents an attractive alternative. The present review summarizes the current knowledge on the differentiation of insulin-producing cells from human embryonic stem cells and their application to the cell therapy for treating diabetes mellitus.
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KEYWORD
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Human embryonic stem cells, Pancreatic β cells, Differentiation, Diabetes mellitus, Cell therapy
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